0577 Sleep Quality and Its Association with Inflammation Over Time in Patients Undergoing Radiation Therapy for Head and Neck Cancer

Abstract Introduction Sleep disturbance is a prominent concern in patients with cancer detrimental effect on health outcomes. Although inflammation has been proposed as potential mechanism of sleep disturbance, there dearth longitudinal data supporting the relationship between cancer-related and inflammatory markers. The goal this prospective study was to examine change quality its association markers undergoing radiation therapy for head neck cancer. Methods A total 176 who had without distant metastases were assessed before, immediately after, at 3 12 months after radiotherapy. by Pittsburgh Quality Index (PSQI). Peripheral blood measured using standard techniques same four assessment times. Generalized estimating equations exchangeable within-subject correlation matrix used analyze repeated measures. Results participants mostly middle-aged White (79.5%) men (74.0%) married or living significant others (70.0%) received concurrent chemoradiotherapy (80.1%). Using PSQI 5 cut-off, 66.3% poor sleepers baseline, rate increased 82.8% then dropped 56.8% 46.2% therapy. Being single (p=0.007), taking antidepressants (p=0.020), feeding tube (p=0.01) identified be significantly associated over time. Controlling relevant demographic clinical factors, changes circulating levels two markers, C-reactive protein (CRP) interlukin-1 receptor antagonist (IL-1ra). Increased CRP IL-1ra higher global scores (beta=0.826, p=0.007 CRP; beta=1.412, p=0.050 IL-1ra), indicating worse quality. Conclusion Patients experienced quality, especially treatment completion those single, depressed, tube. Inflammation both may targets promote outcomes Support (If Any) supported NIH/NINR K99/R00NR014587, R01NR015783, NIH/NCI P30CA138292.